The attackers, which carried AK-47s, entered Radio Television Afghanistan (RTA) on Wednesday and engaged in a gun battle with security forces.
Two of them detonated their vests and at least one remains at large, police said.
"So far, there have been two people and six wounded, including journalists," Al Jazeera's John Hendren, reporting from Afghanistan's capital, Kabul, said.
"The fight could go on for some time because this is in a central part of Jalalabad, right next to the provincial governor's office and a busy square," he added.
There was no immediate claim of responsibility for the attack.
Jalalabad is the capital of Afghanistan's Nangarhar province, on the eastern border with Pakistan.
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